Mouse Anti-Human TIE-2-FITC
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| Cat-Nr. | 101-M54S-FITC |
| Size | 25 µg |
| Price | p.i. € |
| Category | Monoclonal Antibody |
| Label | FITC |
| Clone Nr. | (#tek16) |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Formulation | liquid |
| Buffer | PBS |
| Stabilizer/Carrier | 1% BSA, 0.02% sodium azide |
| Stability and Storage | Store protected from light at 2-8°C. Do not freeze! |
| Preparation | The monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular TIE-2 as the immunizing antigen. Mouse IgG1 antibody (#tek16) from hybridomas was purified from cell culture supernatant by Protein G chromatography and then biotinylated using a standard protocol. The unconjugated antibody will detect native human TIE-2/tek in ELISA experiments and on the surface of different human cell types. |
| Antigen | recombinant human soluble extracellular TIE-3 |
| Application | FC |
| Synonyms | TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B |
| Description | Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects. |
| Uniprot ID | Q02763 |
| Protein RefSeq | NP_000450.2 |
| mRNA RefSeq | NM_000459.3 |
Figures
FACS analysis with primary human dermal lymphatic endothelial cells (HDLEC).
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