Rat Anti-Mouse VEGFR-1/Flt-1

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Size100 µg
Price380 €
CategoryMonoclonal Antibody
Clone Nr.(#5F13)
Species ReactivityMouse
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse VEGFR-1 extracellular domain. IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenmouse VEGFR1 extracellular domain
ApplicationWB, IHC (P)
Synonymsvascular endothelial growth factor receptor-1; FLT1; VEGF receptor 1
DescriptionVascular Endothelial Growth Factor (VEGF or VEGF-A) family members are major mediators of vasculogenesis and angiogenesis. Specifically, biological activities attributed to VEGFs include: mitogenic activity on endothelial cells, increased permeability of endothelial cells to proteins, stimulation of monocyte migration across endothelial cells and angiogenic activity. Three VEGF family receptors have been described: Flt-1 (fms-like tyrosine kinase) also known as VEGF R1, KDR (kinase-insert domain-containing receptor) also known as Flk-1 and VEGF R2, and Flt-4 also known as VEGF R3. The three receptors contain seven extracellular immunoglobulin-like domains and share substantial sequence homology. In addition, neuropilin-1, a neuronal receptor, also acts as a co-receptor for VEGF when expressed on vascular endothelial cells, endothelial cell progenitors and monocytes. VEGF R1 is expressed primarily on endothelial cells but is also found on human peripheral blood monocytes. Through its endothelial mitogenic and hyperpermeability activities, VEGF influences a variety of immune functions related to wound healing and blood protein traffic across endothelial barriers.
Uniprot IDP35969
Protein RefSeqNP_034358.2
mRNA RefSeqNM_010228.3


  1. Motor neurons control blood vessel patterning in the developing spinal cord. P. Himmels et al., Nat Commun. 2017; 8: 14583.

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